December 3, 2021

ACN News

Area Control Network News | Breaking News

Low vitamin D and increased mortality

Lower levels of vitamin D, higher rates of death

Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496747/

Observational study, non-interventional

Background

Vitamin D, lower levels, common in patients with cardiovascular disease (CVD)

Study of patients with existing CVD

Prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with,

All-cause mortality and,

cause-specific mortality

Methods

N = 37,079 patients with CVD from the UK

Biobank study

From a prospective cohort of half a million, aged 40–69 years

https://www.ukbiobank.ac.uk

CVD

Coronary heart disease

Atrial fibrillation

Heart failure

Stroke

Results

Among 37,079 patients with CVD at baseline, 57.5% were vitamin D deficient

Deficient, 25[OH]D less than 50 nmol/L (less than 20ng/ml)

Median follow-up of 11.7 years

Deaths that occurred = 6,319 total

2,161 deaths from CVD

2,230 deaths from cancer

623 deaths from respiratory disease

1,305 other-cause deaths

Non-linear inverse associations

For all-cause mortality

Cancer mortality

Respiratory disease mortality

Other-cause mortality

That is deaths went up as vitamin D levels went down

(P-non-linearity less than 0.01)

Approximately linear inverse associations for CVD

That is deaths went up as vitamin D levels went down

(P-non-linearity = 0.074)

Among CVD patients with vitamin D deficiency

For every 10 nmol/L increment in serum 25(OH)D concentrations,

There was an associated 12% reduced risk for all-cause mortality

There was an associated 9% reduced risk for CVD mortality.

In patients with vitamin D deficiency

Per 10 nmol/L increase in serum 25(OH)D levels,

was associated with a lower risk of mortality from (aHR]; 95% CI)

All-cause 0.88

CVD 0.91

Cancer 0.90

Respiratory diseases 0.81

Other causes 0.81

Multivariable Cox regression models

Age, sex, alcohol, BMI, GFR, education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol

Conclusion

Among patients with existing CVD,

increasing levels in serum 25(OH)D,

were independently associated with a decreased risk of all-cause and cause-specific mortality

These findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.

Therefore

Patients with vitamin D deficiency may benefit more from an increase in serum levels,

than those with CVD and serum 25(OH)D levels of less than 50 nmol/L (less than 20ng/ml)

Our findings provided novel clues
awaiting further validation in clinical trials.

COVID News Source: Dr. John Campbell

World News

The Military News

https://www.youtube.com/watch?v=DTCppdqnuKA NORFOLK, Va. (Dec. 1, 2021) The aircraft carrier USS Harry S. Truman (CVN 75) departs Naval Station Norfolk Dec. 1, as part of Harry...

https://www.youtube.com/watch?v=LQIXnRBL_PE This Is Why the Zumwalt DDG-1000 Stealth Destroyer is not called a Battleship Zumwalt is a heavy hitter whose reach is woefully short. Over...

https://www.youtube.com/watch?v=rg0vZqxTta8 Coming Soon New F-22 Raptor After Upgrade The Lockheed Martin F-22 Raptor is an advanced stealth tactical fighter jet, exclusively used by the US...

https://www.youtube.com/watch?v=h7nQfa0En9E ANNAPOLIS, Md.-- Navy Athletics and Under Armour unveiled a special, naval-aviation themed uniform today that the Navy football team will wear for the Dec....

https://www.youtube.com/watch?v=MGTYbv1OTQI These 5 Weapons Would Spearhead a Marine Invasion of North Korea U.S. Marines would be the first to enter the fight on the ground....

https://www.youtube.com/watch?v=DGPj5iAYsUQ Video shows an explosion caused by an EOD bomb disposal burying the camera placed to film the event. WarLeaks - Military Blog covers events,...

https://www.youtube.com/watch?v=qH3ov8eZF3Q U.S. Army Sgt. Nate Staskiewicz won the Tactical Optics Champion title at the recent Vortex Shootout 3 Gun! Just take a look at one...

https://www.youtube.com/watch?v=SpvV5kAqm58 This is Military Dogs that Are Specially Trained for Combat Dogs trained for military use as attack dogs, most often called patrol dogs, can...

https://www.youtube.com/watch?v=DoTLgRxlIRg A 2017 Pentagon report to Congress detailing production retail costs for Lockheed Martin’s F-22 Raptor show that reviving the powerful stealth air superiority fighter...

https://www.youtube.com/watch?v=39fYUXX11Tc SAN DIEGO (Nov. 8, 2021) A Mercy Exercise (MERCEX) 22-1 conclusion video featuring Sailors embarked with the Medical Treatment Facility (MTF) aboard Military Sealift...

https://www.youtube.com/watch?v=4NcenKQik8o War has a long history that dates back to the dawn of civilization, but armies have come a long way since the spear, or...

https://www.youtube.com/watch?v=63_Y-PJtmpc NATO Allies face many challenges as they patrol and defend their maritime areas, including the detection and clearing of mines, the monitoring and protection...