January 24, 2022

ACN News

Area Control Network News | Breaking News

Ivermectin or Molnupiravir

Link to featured video

Link to Wefwafwa’s channel
(he needs more subscribers)

Link to support Wefwafwa’s work in Africa

Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin



There are still many nations where vaccines are not yet widely available,

There is a gradual shift in focus, to antiviral drugs,

Adjunctive chemoprophylaxis

Active treatment of new SARS-CoV-2 infections

Post -vaccination breakthrough COVID-19 cases

The two ways to get new drugs

Develop novel antiviral drugs for SARS-CoV-2

Repurpose existing FDA -approved drugs to treat COVID-19

Ivermectin is the most studied “repurposed” medication globally,

in randomized clinical trials, retrospective studies and meta- analyses.

Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics

Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,

seasonal or pandemic influenza and MERS corona virus

Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic

and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro


5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours

The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.

Both molnupiravir and ivermectin are well absorbed after oral dosing

Tmax of molnupiravir being 1-1.75 hours,

With a half life of 7 hours

Tmax of ivermectin is 4-6 hours

Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution

Ivermectin has the ability to accumulate in the lungs

The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent

Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA

causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication

There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells

Ivermectin, multifarious actions,

Binding to SARS-CoV-2 spike protein S

Reducing cell entry via human ACE2 receptors

Reducing viral transcription

Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)

Complimentary pharmacokinetics and pharmacodynamics of the drugs

May be additive or synergistic

This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.

A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.



The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.

Say, 12mg per day for 5 days = $0.53







For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence


Early treatment

Late treatment



Main results, Treating people in hospital with COVID-19

We don’t know whether ivermectin compared with placebo or usual care, 28 days after treatment:–

leads to more or fewer deaths

worsens or improves patients’ condition assessed by need for ventilation or oxygen

increases or reduces unwanted events

Preventing COVID-19

We don’t know whether ivermectin leads to more or fewer deaths compared with no drug

COVID News Source: Dr. John Campbell

World News

The Military News

https://www.youtube.com/watch?v=IQkDgvRm4xI USS Harry S. Truman Visits Chania, Greece during a recent port call to Souda Bay, Greece. Source: U.S. Navy

https://www.youtube.com/watch?v=9mcOGuIFrGI PHILIPPINE SEA (Jan. 22, 2022) Aircraft assigned to Carrier Air Wing (CVW) 2, CVW 9 and Japan Maritime Self-Defense Force (JMSDF) fly over the...

https://www.youtube.com/watch?v=6JyKM_1p2iU Not Stealth but Deadly: This Is the Best Fighter Jet on Earth The JAS-39 Gripen is the Swedish defense industry’s largest export, financially. The...

https://www.youtube.com/watch?v=mmlwDiW7_FE Video shows Kurdish fighters with air support from U.S. AH-64 Apache helicopters in heavy clashes with ISIS fighters during an attempted massive prison break...

https://www.youtube.com/watch?v=LbnTGxiSt1U Stunning footage recorded by the Mexican military shows the moment an Narco jet escapes an Mexican military helicopter in Jalisco, Mexico. The plane is...

https://www.youtube.com/watch?v=cRll8oJz7sU Today’s look Around the Air Force highlights Air and Space Force leaders meeting with Congress to discuss the negative impacts of not approving a...

https://www.youtube.com/watch?v=HeepWR8QLu4 NAVAL STATION MAYPORT, Fla. (January 18, 2022) Sailors train at Surface Combat Systems Training Command (SCSTC), Detachment Southeast, Littoral Training Facility. All Sailors and...

https://www.youtube.com/watch?v=Rtxb9fOCLn4 Next Generation Squad Weapon: The U.S. Army’s New Super Rifle This is the next-generation squad weapon for the U.S. Army's new super rifle. This...

https://www.youtube.com/watch?v=IQQcGw87ABw Video from about 2015 shows Ukrainian paramilitary instructors shooting live ammunition at their students to prepare them for a possible Russian invasion that could...

https://www.youtube.com/watch?v=ZGtqT2wPlMA PHILIPPINE SEA (Jan. 17, 2022) The Wasp-class amphibious assault ship USS Essex (LHD 2) conducts flight operations while transiting the Philippine Sea, Jan. 17,...

https://www.youtube.com/watch?v=kWftQDB-bOM The Grumman F-14 Tomcat is an American carrier-capable supersonic, twin-engine, two-seat, twin-tail, variable-sweep wing fighter aircraft. The Tomcat was developed for the United States...

https://www.youtube.com/watch?v=yR9LJkQD3RQ PACIFIC OCEAN (Jan. 11, 2022) F-35B Lightning II aircraft attached to Marine Fighter Attack Squadron (VMFA) 122 conduct flight operations for the first time...