Injections versus infections, Pandemic update
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UK
https://coronavirus.data.gov.uk/details/cases
Cases, + 35,475 (rolling 7 day average to 24 December) = 2,288,345
https://covid.joinzoe.com/data#levels-over-time
Hospitalised, + 2,143 = 21,286 (1,529)
Previous peak, 12 April = 21,683
Vaccinated, 616,933
Injections versus infections
Deaths, + 316 = 70,752
Deaths, + 3,062 = 79,349 (COVID mentioned as one of the causes)
Delays
14th December
Cases, + 20,264
27th December
Hospital admissions, 2,143
10.5%
London Ambulance Service
https://www.bbc.co.uk/news/uk-55462701
Emergency calls, 26 December = 7,918
Same as peak of first wave
Up 2,500 on 26 December 2019
NHS England
https://www.theguardian.com/society/2020/dec/27/hospitals-in-england-told-to-free-up-all-possible-beds-for-surging-covid-cases
Entire health service, remain on highest alert, end of March
Mobilise all of the available surge capacity over the coming weeks
Surgical patients to local private facilities
Discharge as many inpatients as possible
Prepare for Nightingale openings
London’s Royal Free Hospital
Cancelled all non-emergency surgery until mid-February
Restricted staff holidays
Sir Jeremy Farrar, Scientific Advisory Group for Emergencies
https://www.bbc.co.uk/news/live/world-55464932
Reopening schools in January very finely balanced
It is going be a trade-off between one or other
You cannot have everything.
You cannot have the whole of society opening, and schools opening and further education and universities,
and keep R below one with this variant
A British national disgrace
https://www.tagesanzeiger.ch/200-briten-aus-verbier-geflohen-748162397767
https://www.theguardian.com/world/2020/dec/27/hundreds-uk-tourists-flee-covid-quarantine-swiss-ski-resort-verbier
Verbier
UK to Switzerland flights stopped 20 December
Swiss authorities, 21 December
Arrivals from UK since 14 December, need to self-isolate for 10 days
Swiss authorities tracked down 420
Half missing, geflohen, some later reporting to hotels in France
Some rang hotels later to try to get money back
2020 12 Variant
Denmark, Germany, Singapore, France, Japan, Spain, Australia, Lebanon, Sweden, Netherlands, Italy, Canada
United States
CDC trends (Saturday, 28th December)
https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases
Official US hospitalizations
https://gis.cdc.gov/grasp/COVIDNet/COVID19_3.html
Last reliable data, 21st November
Cases, + 152,461 = 18,907,656
Up 7.1% over past 7 days
Hospitalizations, 118,720 (22,447) (7,878)
Deaths, 324,796
https://covidtracking.com
Storm Chaser, Phase 3
Double blind
Placebo controlled
https://clinicaltrials.gov/ct2/show/NCT04625972
https://www.theguardian.com/world/2020/dec/25/uk-scientists-trial-drug-to-prevent-coronavirus-infection-leading-to-disease
AZD7442 monoclonal antibodies
Two mAbs to the SARS-CoV-2 S protein RBD
Six to 12 months
Fc Amino acid substitutions
Extend their half-lives
Decrease Fc effector function to decrease the potential risk of antibody-dependent enhancement of disease
Started 2nd December
N = 1,125 people globally
Healthcare workers
Students in shared accommodation
Recently exposed patients
Long-term care
Military
Factory workers
Timetable
Reports, 4th January
Approval, March or April
UCLH virologist Dr Catherine Houlihan
We know that this antibody combination can neutralise the virus,
so we hope to find that giving this treatment via injection can lead to immediate protection against the development of Covid-19 in people who have been exposed
Provent trial
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